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Recombinant Domain of Flagellin Promotes In Vitro a Chemotactic Inflammatory Profile in Human Immune Cells Independently of a Dendritic Cell Phenotype.

Molecules (Basel, Switzerland) - 5 Mar 2023

González-Stegmaier Roxana, Aguirre Adam, Cárcamo Constanza, Aguila-Torres Patricia, Villarroel-Espíndola Franz

Abstract excerpt

Flagellin is the major component of the flagellum in gram-positive and -negative bacteria and is also the ligand for the Toll-like receptor 5 (TLR5). The activation of TLR5 promotes the expression of proinflammatory cytokines and chemokines and the subsequent activation of T cells. This study evaluated a recombinant domain from the amino-terminus D1 domain (rND1) of flagellin from Vibrio anguillarum, a fish...

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Identifiers

PMID: 36903639
DOI: 10.3390/molecules28052394
PMCID: PMC10005431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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