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Flagellin Induces Myeloid-Derived Suppressor Cells: Implications for <i>Pseudomonas aeruginosa</i> Infection in Cystic Fibrosis Lung Disease

1 Jan 2013

Abstract excerpt

Pseudomonas aeruginosa persists in patients with cystic fibrosis (CF) and drives CF lung disease progression. P. aeruginosa potently activates the innate immune system, mainly mediated through pathogen-associated molecular patterns, such as flagellin. However, the host is unable to eradicate this flagellated bacterium efficiently. The underlying immunological mechanisms are incompletely understood....

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PMID: 23277486
DOI: 10.4049/jimmunol.1202144

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