Article
Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
European journal of immunology - 1 Jun 2012
Kassianos Andrew J, Hardy Melinda Y, Ju Xinsheng, Vijayan Dipti, Ding Yitian, Vulink Annelie J E, McDonald Kylie J, Jongbloed Sarah L, Wadley Robert B, Wells Christine, Hart Derek N J, Radford Kristen J
Abstract excerpt
Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions. CD1c(+) DCs express TLR4 while CD141(+) DCs do not, thus predicting that these two subsets have differential capacities to respond to Escherichia coli. We isolated highly purified CD1c(+) and CD141(+) DCs and compared them to in vitro...
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