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Article

Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.

Journal of leukocyte biology - 1 Oct 2005

Tsujimoto Hironori, Uchida Takefumi, Efron Philip A, Scumpia Philip O, Verma Amrisha, Matsumoto Tadashi, Tschoeke Sven K, Ungaro Ricardo F, Ono Satoshi, Seki Shuhji, Clare-Salzler Michael J, Baker Henry V, Mochizuki Hidetaka, Ramphal Reuben, Moldawer Lyle L

Abstract excerpt

Flagellin, the principal component of bacterial flagella, is a ligand for Toll-like receptor 5 (TLR5) or TLR11 and contributes to systemic inflammation during sepsis through activation of dendritic cells (DCs) and other cells of the innate immune system. Here, we report that flagellin and the TLR4 ligand, lipopolysaccharide (LPS), induced phenotypic and functional maturation of murine bone marrow-derived DCs and...

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Source

Identifiers

PMID: 16033815
DOI: 10.1189/jlb.0105051

Genes

TLR4
TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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