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Article

PARP-1 Expression Influences Cancer Stem Cell Phenotype in Colorectal Cancer Depending on p53.

International journal of molecular sciences - 1 Mar 2023

Puentes-Pardo Jose D, Moreno-SanJuan Sara, Casado Jorge, Escudero-Feliu Julia, López-Pérez David, Sánchez-Uceta Paula, González-Novoa Paula, Gálvez Julio, Carazo Ángel, León Josefa

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a protein involved in multiple physiological processes. Elevated PARP-1 expression has been found in several tumours, being associated with stemness and tumorigenesis. In colorectal cancer (CRC), some controversy among studies has been described. In this study, we analysed the expression of PARP-1 and cancer stem cell (CSC) markers in CRC patients with different p53...

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Source

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Identifiers

PMID: 36902215
DOI: 10.3390/ijms24054787
PMCID: PMC10002521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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