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Article

PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression

9 Apr 2018

Abstract excerpt

Significance Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA repair protein and part of the genome maintenance network. On the other hand, PARP-1 is involved in pathophysiological processes such as inflammation. Chronic inflammation has emerged as a key event in carcinogenesis, including the formation of colorectal cancer (CRC). Our data reveal that PARP-1 is abundantly expressed in human CRC, correlating with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29632181
DOI: 10.1073/pnas.1712345115

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