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Article

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells.

Cell death and differentiation - 1 Feb 2014

Venere M, Hamerlik P, Wu Q, Rasmussen R D, Song L A, Vasanji A, Tenley N, Flavahan W A, Hjelmeland A B, Bartek J, Rich J N

Abstract excerpt

Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is attributed to an augmented response to genotoxic stress. We now report that GICs are primed to handle additional stress due to basal activation of single-strand break repair (SSBR), the main DNA damage response...

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Identifiers

PMID: 24121277
DOI: 10.1038/cdd.2013.136
PMCID: PMC3890948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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