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PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy

11 Jul 2025

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is the third most prevalent cancer worldwide. Despite substantial advancements in CRC therapy in recent years, ionizing radiation (IR) continues to be the predominant treatment for colon malignances. However, it still lacks the precision required for excellent therapeutic outcomes, ultimately resulting in tumor radioresistance. This study seeks to explore the potential of...

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PMID: 40646573
DOI: 10.1186/s13046-025-03439-y

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