Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Let-7i Reduces Aggressive Phenotype and Induces BRCAness in Ovarian Cancer Cells

15 Sept 2021

Abstract excerpt

High-grade serous carcinoma of the ovary is a deadly gynecological cancer with poor long-term survival. Dysregulation of microRNAs has been shown to contribute to the formation of cancer stem cells (CSCs), an important part of oncogenesis and tumor progression. The let-7 family of microRNAs has previously been shown to regulate stemness and has tumor suppressive actions in a variety of cancers, including ovarian....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to MicroRNA in disease regulation
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34572843
DOI: 10.3390/cancers13184617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Let-7i Reduces Aggressive Phenotype and Induces BRCAness in Ovarian Cancer CellsPMID 34572843Read ↗

Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1Semantic proximity Read ↗

The Epithelial–Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in CancerSemantic proximity Read ↗

Regulation of Ovarian Cancer Stem Cells or Tumor-Initiating CellsSemantic proximity Read ↗

Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repairSemantic proximity Read ↗

SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer CellsSemantic proximity Read ↗

Let-7: A regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cellsSemantic proximity Read ↗

The Role of MicroRNAs in Breast Cancer Stem CellsSemantic proximity Read ↗

MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistanceSemantic proximity Read ↗

The molecular mechanisms and therapeutic potential of microRNA-7 in cancerSemantic proximity Read ↗

MicroR-760 suppresses cancer stem cell subpopulation and breast cancer cell proliferation and metastasis: By down-regulating NANOGSemantic proximity Read ↗

The epithelial-mesenchymal transcription factor <i>SNAI1</i> represses transcription of the tumor suppressor miRNA <i>let-7</i> in cancerSemantic proximity Read ↗

Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.