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Article

PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.

Oncotarget - 27 Sept 2016

Karicheva Olga, Rodriguez-Vargas José Manuel, Wadier Nadège, Martin-Hernandez Kathline, Vauchelles Romain, Magroun Najat, Tissier Agnès, Schreiber Valérie, Dantzer Françoise

Abstract excerpt

Several members of the Poly(ADP-ribose) polymerase (PARP) family are essential regulators of genome integrity, actively prospected as drug targets for cancer therapy. Among them, PARP3 is well characterized for its functions in double-strand break repair and mitotis. Here we report that PARP3 also plays an integral role in TGFβ and reactive oxygen species (ROS) dependent epithelial-to-mesenchymal transition (EMT)...

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Source

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Identifiers

PMID: 27579892
DOI: 10.18632/oncotarget.11627
PMCID: PMC5325429

Genes

PARP3
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.PMID 27579892Read ↗

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