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Article

PARP in colorectal cancer: Molecular mechanisms, immunity, clinical trials, and drug combinations

2 Sept 2022

Abstract excerpt

The changes in cell homeostasis in the tumor microenvironment may affect the development of colorectal cancer (CRC). Genomic instability is an important factor. Persistent genomic instability leads to epigenetic changes, and mutations are a major factor in the progression of CRC. Based on these mechanisms, it is reasonable to link poly (ADP-ribose) polymerase (PARP) with the treatment of CRC. PARP is mainly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36129834
DOI: 10.4149/neo_2022_220724n745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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