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CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2

28 Feb 2023

Abstract excerpt

Several reports have indicated that SARS-CoV-2 infection displays unexpected mild clinical manifestations in people with cystic fibrosis (pwCF), suggesting that CFTR expression and function may be involved in the SARS-CoV-2 life cycle. To evaluate the possible association of CFTR activity with SARS-CoV-2 replication, we tested the antiviral activity of two well-known CFTR inhibitors (IOWH-032 and PPQ-102) in wild...

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PMID: 36899912
DOI: 10.3390/cells12050776

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