Article

The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting viral replication-transcription complex in culture cells

2020-08-24

Abstract excerpt

We screened steroid compounds to obtain a drug expected to block host inflammatory responses and MERS-CoV replication. Ciclesonide, an inhaled corticosteroid, suppressed replication of MERS-CoV and other coronaviruses, including SARS-CoV-2, the cause of COVID-19, in cultured cells. The effective concentration (EC 90 ) of ciclesonide for SARS-CoV-2 in differentiated human bronchial tracheal epithelial cells was 0....

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Literature Corpus work: 1381d94e-78dc-59ea-8244-4b0e68031c7a
DOI: 10.1101/2020.08.22.258459

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