Article
Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2023
Tedbury Philip R, Manfredi Candela, Degenhardt Frauke, Conway Joseph, Horwath Michael C, McCracken Courtney, Sorscher Adam J, Moreau Sandy, Wright Christine, Edwards Carolina, Brewer Jo, Guarner Jeannette, de Wit Emmie, Williamson Brandi N, Suthar Mehul S, Ong Yee T, Roback John D, Alter David N, Holter Jan C, Karlsen Tom H, Sacchi Nicoletta, Romero-Gómez Manuel, Invernizzi Pietro, Fernández Javier, Buti Maria, Albillos Agustin, Julià Antonio, Valenti Luca, Asselta Rosanna, Banales Jesus M, Bujanda Luis, de Cid Rafael, Franke André, Sarafianos Stefan G, Hong Jeong S, Sorscher Eric J, Ehrhardt Annette
Abstract excerpt
Patients with cystic fibrosis (CF) exhibit pronounced respiratory damage and were initially considered among those at highest risk for serious harm from SARS-CoV-2 infection. Numerous clinical studies have subsequently reported that individuals with CF in North America and Europe-while susceptible to severe COVID-19-are often spared from the highest levels of virus-associated mortality. To understand features...
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