Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

doi:10.1021/acs.jmedchem.6b01521

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Article

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

Journal of medicinal chemistry - 23 Feb 2017

Tassini Sabrina, Sun Liang, Lanko Kristina, Crespan Emmanuele, Langron Emily, Falchi Federico, Kissova Miroslava, Armijos-Rivera Jorge I, Delang Leen, Mirabelli Carmen, Neyts Johan, Pieroni Marco, Cavalli Andrea, Costantino Gabriele, Maga Giovanni, Vergani Paola, Leyssen Pieter, Radi Marco

Abstract excerpt

Enteroviruses (EVs) are among the most frequent infectious agents in humans worldwide and represent the leading cause of upper respiratory tract infections. No drugs for the treatment of EV infections are currently available. Recent studies have also linked EV infection with pulmonary exacerbations, especially in cystic fibrosis (CF) patients, and the importance of this link is probably underestimated. The aim of...

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PMID: 28122178
DOI: 10.1021/acs.jmedchem.6b01521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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