Article
A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.
The Journal of infectious diseases - 5 Dec 2017
Svedin Emma, Utorova Renata, Hühn Michael H, Larsson Pär G, Stone Virginia M, Garimella Manasa, Lind Katharina, Hägglöf Thomas, Pincikova Terezia, Laitinen Olli H, McInerney Gerald M, Scholte Bob, Hjelte Lena, Karlsson Mikael C I, Flodström-Tullberg Malin
Abstract excerpt
Acute respiratory virus infections predispose the cystic fibrosis (CF) lung to chronic bacterial colonization, which contributes to high mortality. For reasons unknown, respiratory virus infections have a prolonged duration in CF. Here, we demonstrate that mice carrying the most frequent cystic fibrosis transmembrane conductance regulator (CFTR) mutation in humans, ΔF508, show increased morbidity and mortality...
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