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Article

Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2018

Ruffin Manon, Roussel Lucie, Maillé Émilie, Rousseau Simon, Brochiero Emmanuelle

Abstract excerpt

Cystic fibrosis patients exhibit chronic Pseudomonas aeruginosa respiratory infections and sustained proinflammatory state favoring lung tissue damage and remodeling, ultimately leading to respiratory failure. Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function is associated with MAPK hyperactivation and increased cytokines expression, such as interleukin-8 [chemoattractant chemokine...

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Source

Identifiers

PMID: 29351441
DOI: 10.1152/ajplung.00198.2017

Genes

CFTR
CXCL8
CXCL1
CXCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells.PMID 29351441Read ↗

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