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Article

Dual-mechanism therapy for chronic rhinosinusitis via siRNA targeting of bacterial 16S rRNA and disruption of CFTR-pathogen interactions.

Brazilian journal of otorhinolaryngology - 1 Jan 2026

Wei Bo, He Jiaoyu, Li Jiaxin, Liu Feng

Abstract excerpt

OBJECTIVE(S): This study aimed to develop a dual-mechanism therapeutic strategy for Chronic Rhinosinusitis (CRS) associated with Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mutations. Specifically, we sought to (1) Design siRNAs targeting conserved regions of the bacterial 16S rRNA gene to reduce pathogen viability and (2) Investigate the interaction between mutant CFTR (PDB: 1XMJ) and a bacterial...

Read the complete abstract on PubMed

Topics

Rhinosinusitis
Cystic Fibrosis Transmembrane Conductance Regulator
Humans
RNA, Small Interfering
RNA, Ribosomal, 16S
Biofilms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chronic Disease

Pseudomonas aeruginosa

Molecular Docking Simulation

Mutation

Surface Plasmon Resonance

Rhinitis

Source

Open in PubMed Open full text

Identifiers

PMID: 42302461
DOI: 10.1016/j.bjorl.2026.101851
PMCID: PMC13285275

Genes

CFTR
GC
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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