Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

10 Jan 2023

Abstract excerpt

Three highly pathogenic human CoVs have been identified: SARS-CoV, MERS-CoV, and SARS-CoV-2. The E protein PBMs of these three CoVs were virulence factors. Gene expression patterns associated with the different PBM motifs in the lungs of infected mice were analyzed by deep sequencing. E protein PBM motif of SARS-CoV and SARS-CoV-2 dysregulated the expression of genes related to ion transport and cell homeostasis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis Research Advances
Share to Respiratory Support and Mechanisms
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36625656
DOI: 10.1128/mbio.03136-22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator ModulatorsPMID 36625656Read ↗

CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial CellsSemantic proximity Read ↗

CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2Semantic proximity Read ↗

TGF-β1 Inhibition of ACE2 Mediated by miRNA Uncovers Novel Mechanism of SARS-CoV-2 PathogenesisSemantic proximity Read ↗

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisSemantic proximity Read ↗

Developing inhibitory peptides against SARS-CoV-2 envelope proteinSemantic proximity Read ↗

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronavirusesSemantic proximity Read ↗

Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.Semantic proximity Read ↗

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 TreatmentSemantic proximity Read ↗

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVsSemantic proximity Read ↗

Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 Spike proteinSemantic proximity Read ↗

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infectionSemantic proximity Read ↗

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.