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Article

Structural modeling and analyses of genetic variations in the human XPC nucleotide excision repair protein.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Le Jennifer, Min Jung-Hyun

Abstract excerpt

Xeroderma pigmentosum C (XPC) is a key initiator in the global genome nucleotide excision repair pathway in mammalian cells. Inherited mutations in the XPC gene can cause xeroderma pigmentosum (XP) cancer predisposition syndrome that dramatically increases the susceptibility to sunlight-induced cancers. Various genetic variants and mutations of the protein have been reported in cancer databases and literature....

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Identifiers

PMID: 36890638
DOI: 10.1080/07391102.2023.2177349
PMCID: PMC10485178

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