Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.

doi:10.1073/pnas.1921311117

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Article

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2020

Tsutakawa Susan E, Sarker Altaf H, Ng Clifford, Arvai Andrew S, Shin David S, Shih Brian, Jiang Shuai, Thwin Aye C, Tsai Miaw-Sheue, Willcox Alexandra, Her Mai Zong, Trego Kelly S, Raetz Alan G, Rosenberg Daniel, Bacolla Albino, Hammel Michal, Griffith Jack D, Cooper Priscilla K, Tainer John A

Abstract excerpt

Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA damage responses (DDR) and a pathway coordinator and structure-specific endonuclease in nucleotide excision repair (NER). Different mutations in the XPG gene ERCC5 lead to either of two distinct human diseases: Cancer-prone xeroderma pigmentosum (XP-G) or the fatal neurodevelopmental disorder Cockayne syndrome (XP-G/CS). To...

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Identifiers

PMID: 32522879
DOI: 10.1073/pnas.1921311117
PMCID: PMC7321962

Genes

CS
ERCC5
FEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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