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Computational and Molecular Dynamics Simulation Approach To Analyze the Impact of <i>XPD</i> Gene Mutation on Protein Stability and Function

2020-07-18

Abstract excerpt

XPD acts as a functional helicase and aids in unwinding double helix around damaged DNA, leading to efficient DNA repair. Mutations of XPD give rise to DNA-repair deficiency diseases and cancer proneness. In this study, cancer-causing missense mutation that could inactivate helicase function and hinder its binding with other complexes were analysed using bioinformatics approach. Rigorous computational methods wer...

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Literature Corpus work
d12c0cf3-2792-5b85-abdf-ec9630aa7fc9
DOI
10.1101/2020.07.18.209841
Open publication

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Computational and Molecular Dynamics Simulation Approach To Analyze the Impact of <i>XPD</i> Gene Mutation on Protein Stability and FunctionDOI 10.1101/2020.07.18.209841
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