Article

XPA tumor variants lead to defects in NER that sensitize cells to cisplatin

2023-07-01

Abstract excerpt

Nucleotide excision repair (NER) neutralizes treatment with platinum (Pt)-based chemotherapy by removing Pt lesions from DNA. Previous study has identified that missense mutation or loss of either of the NER genes Excision Repair Cross Complementation Group 1 and 2 ( ERCC1 and ERCC2 ) leads to improved patient outcomes after treatment with Pt-based chemotherapies. Although most NER gene alterations found in pati...

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Literature Corpus work: 1b890ed2-e585-54cd-8d08-aae4a4aab364
DOI: 10.1101/2023.06.29.547124

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