Article
XPC as breast cancer susceptibility gene: evidence from genetic profiling, statistical inferences and protein structural analysis.
Breast cancer (Tokyo, Japan) - 1 Nov 2020
Malik Saima Shakil, Zia Ayisha, Rashid Sajid, Mubarik Sumaira, Masood Nosheen, Hussain Mubashar, Yasmin Azra, Bano Razia
Abstract excerpt
BACKGROUND: Gene polymorphisms that affect nucleotide excision repair (NER) pathway may link with higher susceptibility of breast cancer (BC); however, the significance of these associations may vary conferring to the individual ethnicity. Xeroderma pigmentosum complementation gene (XPC) plays a substantial role in recognizing damaged DNA during NER process. OBJECTIVE AND METHODS: To estimate the relationship...
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