Article
XPA: A key scaffold for human nucleotide excision repair.
DNA repair - 1 Aug 2016
Sugitani Norie, Sivley Robert M, Perry Kelly E, Capra John A, Chazin Walter J
Abstract excerpt
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.
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