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Article

Splicing dysregulation in human hematologic malignancies: beyond splicing mutations.

Trends in immunology - 1 Aug 2022

De Kesel Jonas, Fijalkowski Igor, Taylor Justin, Ntziachristos Panagiotis

Abstract excerpt

Splicing is a fundamental process in pre-mRNA maturation. Whereas alternative splicing (AS) enriches the diversity of the proteome, its aberrant regulation can drive oncogenesis. So far, most attention has been given to spliceosome mutations (SMs) in the context of splicing dysregulation in hematologic diseases. However, in recent years, post-translational modifications (PTMs) and transcriptional alterations of...

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Identifiers

PMID: 35850914
DOI: 10.1016/j.it.2022.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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