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Clinical and genomic features of non-small cell lung cancer occurring in families.

Thoracic cancer - 1 Apr 2023

Miyabe Shingo, Ito Shin, Sato Ikuro, Abe Jiro, Tamai Keiichi, Mochizuki Mai, Fujimori Haruna, Yamaguchi Kazunori, Shindo Norihisa, Shima Hiroshi, Yamazaki Tomoko, Abue Makoto, Okada Yoshinori, Yasuda Jun

Abstract excerpt

BACKGROUND: Exposure to environmental carcinogens, such as through smoking, is a major factor in the carcinogenesis of non-small cell lung cancer (NSCLC). However, genetic factors may also contribute. METHODS: To identify candidate tumor suppressor genes for NSCLC, we included 23 patients (10 related pairs and 3 individuals) with NSCLC who had other NSCLC-affected first-degree relatives in a local hospital. Exome...

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Identifiers

PMID: 36869602
DOI: 10.1111/1759-7714.14825
PMCID: PMC10067361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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