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Article

Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy-driven Metabolic Reprogramming.

Cancer research communications - 1 Feb 2023

McClure Marni B, Kogure Yasunori, Ansari-Pour Naser, Saito Yuki, Chao Hann-Hsiang, Shepherd Jonathan, Tabata Mariko, Olopade Olufunmilayo I, Wedge David C, Hoadley Katherine A, Perou Charles M, Kataoka Keisuke

Abstract excerpt

The hallmark signatures based on gene expression capture core cancer processes. Through a pan-cancer analysis, we describe the overview of hallmark signatures across tumor types/subtypes and reveal significant relationships between these signatures and genetic alterations. TP53 mutation exerts diverse changes, including increased proliferation and glycolysis, which are closely mimicked by widespread copy-number...

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Source

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Identifiers

PMID: 36860655
DOI: 10.1158/2767-9764.CRC-22-0073
PMCID: PMC9973382

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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