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Overcoming anoikis – pathways to anchorage-independent growth in cancer

22 Sept 2011

Abstract excerpt

Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use to eliminate 'misplaced' cells, i.e. cells that are in an inappropriate location. Occasionally, detached or misplaced cells can overcome anoikis and survive for a certain period of time in the absence of the correct signals from the extracellular matrix (ECM). If cells are able to adapt to their new environment, then they...

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PMID: 21940791
DOI: 10.1242/jcs.072165

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