Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.

doi:10.1038/s41388-022-02368-w

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Article

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.

Oncogene - 1 Jul 2022

Datta Jashodeep, Bianchi Anna, De Castro Silva Iago, Deshpande Nilesh U, Cao Long Long, Mehra Siddharth, Singh Samara, Rafie Christine, Sun Xiaodian, Chen Xi, Dai Xizi, Colaprico Antonio, Sharma Prateek, Dosch Austin R, Pillai Asha, Hosein Peter J, Nagathihalli Nagaraj S, Komanduri Krishna V, Wilson Julie M, Ban Yuguang, Merchant Nipun B

Abstract excerpt

Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS-TP53 co-alteration is associated with worse survival compared with either KRAS-alone or TP53-alone altered PDAC in 245 patients with metastatic disease treated at a tertiary referral cancer center, and validate this observation in...

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PMID: 35701533
DOI: 10.1038/s41388-022-02368-w

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