Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4.

doi:10.1002/path.4884

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Article

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4.

The Journal of pathology - 1 May 2017

Hosoda Waki, Chianchiano Peter, Griffin James F, Pittman Meredith E, Brosens Lodewijk Aa, Noë Michaël, Yu Jun, Shindo Koji, Suenaga Masaya, Rezaee Neda, Yonescu Raluca, Ning Yi, Albores-Saavedra Jorge, Yoshizawa Naohiko, Harada Kenichi, Yoshizawa Akihiko, Hanada Keiji, Yonehara Shuji, Shimizu Michio, Uehara Takeshi, Samra Jaswinder S, Gill Anthony J, Wolfgang Christopher L, Goggins Michael G, Hruban Ralph H, Wood Laura D

Abstract excerpt

High-grade pancreatic intraepithelial neoplasia (HG-PanIN) is the major precursor of pancreatic ductal adenocarcinoma (PDAC) and is an ideal target for early detection. To characterize pure HG-PanIN, we analysed 23 isolated HG-PanIN lesions occurring in the absence of PDAC. Whole-exome sequencing of five of these HG-PanIN lesions revealed a median of 33 somatic mutations per lesion, with a total of 318 mutated...

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Identifiers

PMID: 28188630
DOI: 10.1002/path.4884
PMCID: PMC5553451

Genes

SMAD4
KRAS
GNAS
RNF43
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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