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Article

Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal.

Scientific reports - 18 Jan 2026

Ba Aboubacar, Thiam Laty Gaye, Pouye Mariama Nicole, Guo Yicheng, Patel Saurabh D, Sene Seynabou Diouf, Diallo Fatoumata, Li Rebecca, Cisse Awa, Guerra Noemi, Laqqa Safia, Mangou Khadidiatou, Moore Adam J, Sadio Bacary Djilocalisse, Ndiaye Jean Louis Abdourahim, Mbengue Alassane, Vigan-Womas Ines, Sheng Zizhang, Shapiro Lawrence, Bei Amy K

Abstract excerpt

The Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is a promising target as a next-generation blood-stage malaria vaccine and together with PCRCR complex members, the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5-interacting protein (PfRipr), are currently being evaluated in clinical trials. PfCyRPA is essential for merozoite invasion and appears to be highly conserved...

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Share to Antigens, Protozoan
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41549078
DOI: 10.1038/s41598-026-36257-z
PMCID: PMC12891623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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