Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene conversion during vector insertion in embryonic stem cells.

Nucleic acids research - 11 Jun 1995

Hasty P, Rivera-Pérez J, Bradley A

Abstract excerpt

Recombination of an insertion vector into its chromosomal homologue is a conservative event in that both the chromosomal and the vector sequences are preserved. However, gene conversion may accompany homologous recombination of an insertion vector. To examine gene conversion in more detail we have determined the targeting frequencies and the structure of the recombinant alleles generated with a series of vectors...

Topics

Alleles
Animals
Base Sequence
Cells, Cultured
DNA Transposable Elements
Electroporation
Genetic Vectors
Molecular Sequence Data
Mutation
Stem Cells

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 7596837
DOI: 10.1093/nar/23.11.2058
PMCID: PMC306984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7596837-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene conversion during vector insertion in embryonic stem cells.PMID 7596837Read ↗

Analysis of gene targeting and intrachromosomal homologous recombination stimulated by genomic double-strand breaks in mouse embryonic stem cells.Semantic proximity Read ↗

Human gene targeting favors insertions over deletions.Semantic proximity Read ↗

Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.Semantic proximity Read ↗

Direct readout of neural stem cell transgenesis with an integration-coupled gene expression switchSemantic proximity Read ↗

Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells.Semantic proximity Read ↗

Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand BreaksSemantic proximity Read ↗

Comprehensive genomic access to vector integration in clinical gene therapySemantic proximity Read ↗

Retroviral integration and human gene therapySemantic proximity Read ↗

Short DNA fragments induce site specific recombination in mammalian cells.Semantic proximity Read ↗

Human gene targeting by adeno-associated virus vectors is enhanced by DNA double-strand breaks.Semantic proximity Read ↗

HTLV-1 Splice Sites in Prevalent Gene Vectors Cause Splicing Perturbations in Transgenic Human CellsSemantic proximity Read ↗

Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.