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Article

Genetic manipulation of the mouse via gene targeting in embryonic stem cells.

Ciba Foundation symposium - 1 Jan 1992

Bradley A, Ramírez-Solis R, Zheng H, Hasty P, Davis A

Abstract excerpt

Gene targeting applied to totipotent embryonic stem (ES) cells is a very powerful means of creating highly specific mutations of genes in the mouse. The successful application of this technology is however constrained by both the types of mutations that can be generated at a target locus and the ability to reconstruct a germline chimera from the manipulated cells. We have developed two cell lines that can be...

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PMID: 1516472
DOI: 10.1002/9780470514221.ch15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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