Article
Genetic manipulation of the mouse via gene targeting in embryonic stem cells.
Ciba Foundation symposium - 1 Jan 1992
Bradley A, Ramírez-Solis R, Zheng H, Hasty P, Davis A
Abstract excerpt
Gene targeting applied to totipotent embryonic stem (ES) cells is a very powerful means of creating highly specific mutations of genes in the mouse. The successful application of this technology is however constrained by both the types of mutations that can be generated at a target locus and the...
Topics
- Animals
- Cell Line
- Clone Cells
- Genetic Vectors
- Germ Cells
- Mice
- Mutation
- Selection, Genetic
- Stem Cells