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Engineering of Human Pluripotent Stem Cells by AAV-mediated Gene Targeting

20 Apr 2010

Abstract excerpt

Precise genetic manipulation of human pluripotent stem cells will be required to realize their scientific and therapeutic potential. Here, we show that adeno-associated virus (AAV) gene targeting vectors can be used to genetically engineer human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Different types of sequence-specific changes, including the creation and correction of mutations,...

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PMID: 20407427
DOI: 10.1038/mt.2010.55

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