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Article

Chromosome transplantation as a novel approach for correcting complex genomic disorders.

Oncotarget - 3 Nov 2015

Paulis Marianna, Castelli Alessandra, Susani Lucia, Lizier Michela, Lagutina Irina, Focarelli Maria Luisa, Recordati Camilla, Uva Paolo, Faggioli Francesca, Neri Tui, Scanziani Eugenio, Galli Cesare, Lucchini Franco, Villa Anna, Vezzoni Paolo

Abstract excerpt

Genomic disorders resulting from large rearrangements of the genome remain an important unsolved issue in gene therapy. Chromosome transplantation, defined as the perfect replacement of an endogenous chromosome with a homologous one, has the potential of curing this kind of disorders. Here we report the first successful case of chromosome transplantation by replacement of an endogenous X chromosome carrying a...

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Identifiers

PMID: 26485770
DOI: 10.18632/oncotarget.6143
PMCID: PMC4742100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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