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Article

The Role of NLRP3 Inflammasome in Lupus Nephritis.

International journal of molecular sciences - 19 Nov 2021

Oliveira Camila Barbosa, Lima Camilla Albertina Dantas, Vajgel Gisele, Sandrin-Garcia Paula

Abstract excerpt

Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the...

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Identifiers

PMID: 34830358
DOI: 10.3390/ijms222212476
PMCID: PMC8625721

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