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Cell‐free chromatin immunoprecipitation can determine tumor gene expression in lung cancer patients

24 Feb 2023

Abstract excerpt

Cell-free DNA (cfDNA) in blood plasma can be bound to nucleosomes that contain post-translational modifications representing the epigenetic profile of the cell of origin. This includes histone H3 lysine 36 trimethylation (H3K36me3), a marker of active transcription. We hypothesised that cell-free chromatin immunoprecipitation (cfChIP) of H3K36me3-modified nucleosomes present in blood plasma can delineate tumour...

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PMID: 36825535
DOI: 10.1002/1878-0261.13394

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