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Article

EGFR transcription in non-small-cell lung cancer tumours can be revealed in ctDNA by cell-free chromatin immunoprecipitation (cfChIP).

Molecular oncology - 1 Nov 2021

Månsson Christoffer Trier, Vad-Nielsen Johan, Meldgaard Peter, Nielsen Anders Lade, Sorensen Boe Sandahl

Abstract excerpt

Determination of tumour-specific transcription based on liquid biopsies possesses a large diagnostic and prognostic potential in non-small cell lung cancer (NSCLC). Cell-free DNA (cfDNA) packed in nucleosomes mirrors the histone modification profiles present in the cells of origin. H3 lysine 36 trimethylation (H3K36me3)-modified nucleosomes are associated with active genes, and therefore, cell-free chromatin...

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Identifiers

PMID: 34453867
DOI: 10.1002/1878-0261.13093
PMCID: PMC8564636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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