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Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes

25 Jan 2024

Abstract excerpt

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability. Given the known epigenetic regulation of critical SCLC transcriptional programs, we hypothesized that subtype-specific patterns of DNA methylation could be detected in tumor or blood from SCLC...

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PMID: 38278149
DOI: 10.1016/j.ccell.2024.01.001

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