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Cell-free and extrachromosomal DNA profiling of small cell lung cancer.

Trends in molecular medicine - 1 Jan 2025

Behrouzi Roya, Clipson Alexandra, Simpson Kathryn L, Blackhall Fiona, Rothwell Dominic G, Dive Caroline, Mouliere Florent

Abstract excerpt

Small cell lung cancer (SCLC) is highly aggressive with poor prognosis. Despite a relative prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently implemented, unlike non-SCLC where cell-free DNA (cfDNA) mutation profiling in the blood has utility for guiding targeted therapies and assessing minimal residual disease. cfDNA methylation profiling is highly sensitive for SCLC...

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Identifiers

PMID: 39232927
DOI: 10.1016/j.molmed.2024.08.004

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