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NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates

16 Aug 2023

Abstract excerpt

Cellular senescence, characterized by stable cell cycle arrest, plays an important role in aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged tissues and ameliorates age-associated diseases. Here, we identified that natural killer group 2 member D ligands (NKG2DLs) are up-regulated in senescent cells in vitro, regardless of stimuli that induced cellular senescence, and in various...

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PMID: 37585504
DOI: 10.1126/scitranslmed.add1951

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