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Article

Structure of Dicer and mechanistic implications for RNAi.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2006

Macrae I J, Li F, Zhou K, Cande W Z, Doudna J A

Abstract excerpt

Dicer is a specialized ribonuclease that processes double-stranded RNA (dsRNA) into small RNA fragments about 25 nucleotides in length during the initiation phase of RNA interference (RNAi). We previously determined the crystal structure of a Dicer enzyme from the diplomonad Giardia intestinalis and proposed a structural model for dsRNA processing. Here, we provide evidence that Dicer is composed of three...

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Source

Identifiers

PMID: 17381283
DOI: 10.1101/sqb.2006.71.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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