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Article

A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer.

Molecular cell - 20 Feb 2014

Tian Yuan, Simanshu Dhirendra K, Ma Jin-Biao, Park Jong-Eun, Heo Inha, Kim V Narry, Patel Dinshaw J

Abstract excerpt

We have solved two families of crystal structures of the human Dicer "platform-PAZ-connector helix" cassette in complex with small interfering RNAs (siRNAs). The structures possess two adjacently positioned pockets: a 2 nt 3'-overhang-binding pocket within the PAZ domain (3' pocket) and a phospha...

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Share to Crystallography, X-Ray
Share to DEAD-box RNA Helicases
Share to Phosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Secondary

Share to Ribonuclease III

Share to RNA, Small Interfering

Share to Sequence Homology, Amino Acid

Share to Surface Plasmon Resonance

Source

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Identifiers

PMID: 24486018
DOI: 10.1016/j.molcel.2014.01.003
PMCID: PMC4217634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24486018-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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