Sex differences in polygenic risk for sex-biased brain disorders: Associations with diagnostic status and brain age gap

Abstract excerpt

Biological sex influences the prevalence and progression of several brain disorders, yet it remains unclear whether genetic risk interacts with sex in relation to case-control status or brain health. Using data from up to 220 836 females and 187 651 males in the UK Biobank (aged 39–81), we assessed how sex and polygenic risk scores (PRSs) for major depressive disorder (PRS_MDD), Alzheimer’s disease (PRS_AD), schiz...

Topics

Open a Topic to create a Post that cites this publication.

• Sex and Gender in Healthcare

Identifiers and source

Literature Corpus work

b9c08fd8-1fea-5a39-b616-5fde6357eefa

DOI

10.1038/s41398-026-04220-1