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Article

Sex-stratified genome-wide meta-analysis identifies novel loci for cognitive decline in older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2025

Acharya Vibha, Fan Kang-Hsien, Snitz Beth E, Ganguli Mary, DeKosky Steven T, Lopez Oscar L, Feingold Eleanor, Kamboh M Ilyas

Abstract excerpt

INTRODUCTION: Many complex traits and diseases show sex-specific biases in clinical presentation and prevalence. METHODS: To understand sex-specific genetic architecture of cognitive decline across five cognitive domains (attention, memory, executive function, language, and visuospatial function) and global cognitive function, we performed sex-stratified genome-wide meta-analysis in 3021 older adults aged ≥ 65...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40042063
DOI: 10.1002/alz.14461
PMCID: PMC11880917

Genes

MAF
NDUFA12

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