Possible association between SNAP-25 single nucleotide polymorphisms and alterations of categorical fluency and functional MRI parameters in Alzheimer's disease.

doi:10.3233/JAD-140057

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Article

Possible association between SNAP-25 single nucleotide polymorphisms and alterations of categorical fluency and functional MRI parameters in Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Guerini Franca Rosa, Agliardi Cristina, Sironi Manuela, Arosio Beatrice, Calabrese Elena, Zanzottera Milena, Bolognesi Elisabetta, Ricci Cristian, Costa Andrea Saul, Galimberti Daniela, Griffanti Ludovica, Bianchi Anna, Savazzi Federica, Mari Daniela, Scarpini Elio, Baglio Francesca, Nemni Raffaello, Clerici Mario

Abstract excerpt

Synaptosomal-associated protein of 25 kDa (SNAP-25) is an age-regulated vesicular SNARE protein involved in the exocytosis of neurotransmitters from synapses, a process that is altered in Alzheimer's disease (AD). Changes in SNAP-25 levels are suggested to contribute to age-related decline of cognitive function, and single nucleotide polymorphisms (SNPs) in the SNAP-25 gene are present in neuropsychiatric...

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PMID: 25024311
DOI: 10.3233/JAD-140057

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