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Article

The Versatile Gasdermin Family: Their Function and Roles in Diseases

11 Nov 2021

Abstract excerpt

The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved and released to form large oligomeric pores in the membrane that facilitate pyroptosis. The emerging roles of GSDMs...

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Identifiers

PMID: 34858408
DOI: 10.3389/fimmu.2021.751533

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