Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection.

doi:10.1016/j.imbio.2023.152351

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Article

Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection.

Immunobiology - 1 Mar 2023

Tsiftsoglou Stefanos A, Gavriilaki Eleni, Touloumenidou Tasoula, Koravou Evaggelia-Evdoxia, Koutra Maria, Papayanni Penelope Georgia, Karali Vassiliki, Papalexandri Apostolia, Varelas Christos, Chatzopoulou Fani, Chatzidimitriou Maria, Chatzidimitriou Dimitrios, Veleni Anastasia, Rapti Evdoxia, Kioumis Ioannis, Kaimakamis Evaggelos, Bitzani Milly, Boumpas Dimitrios T, Tsantes Argyris, Sotiropoulos Damianos, Papadopoulou Anastasia, Sakellari Ioanna, Kokoris Styliani, Anagnostopoulos Achilles

Abstract excerpt

We have attempted to explore further the involvement of complement components in the host COVID-19 (Coronavirus disease-19) immune responses by targeted genotyping of COVID-19 adult patients and analysis for missense coding Single Nucleotide Polymorphisms (coding SNPs) of genes encoding Alternative pathway (AP) components. We have identified a small group of common coding SNPs in Survivors and Deceased...

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Identifiers

PMID: 36805858
DOI: 10.1016/j.imbio.2023.152351
PMCID: PMC9928680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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