Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population.

doi:10.1007/s00251-025-01386-8

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Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population.

Immunogenetics - 9 Oct 2025

Galisa Steffany Larissa Galdino, de Oliveira Sá Marcus Villander Barros, Tavares Natália Machado, Boaventura Viviane Sampaio, Caldas Juliana Ribeiro, de São Pedro Raquel Bispo, de Souza Carlos Dornels Freire, da Costa Armstrong Anderson, Oliveira Pablo Rafael Silveira, do Carmo Rodrigo Feliciano, Vasconcelos Luydson Richardson Silva

Abstract excerpt

COVID-19, caused by the SARS-CoV-2 virus, has had a global impact, leading to high incidence and mortality rates worldwide. Host genetics significantly influence individual susceptibility to severe COVID-19. The C-type lectin domain family 4 member M (CLEC4M) gene plays an important role in SARS-CoV-2 infection and coagulation pathways. In this study, we genotyped and investigated the functional variant rs868875...

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PMID: 41062837
DOI: 10.1007/s00251-025-01386-8

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CLEC4M

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Source receipt: pubmed, retrieved 7 Sept 2026.

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