Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population.

doi:10.1007/s00251-025-01386-8

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Article

Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population.

Immunogenetics - 9 Oct 2025

Galisa Steffany Larissa Galdino, de Oliveira Sá Marcus Villander Barros, Tavares Natália Machado, Boaventura Viviane Sampaio, Caldas Juliana Ribeiro, de São Pedro Raquel Bispo, de Souza Carlos Dornels Freire, da Costa Armstrong Anderson, Oliveira Pablo Rafael Silveira, do Carmo Rodrigo Feliciano, Vasconcelos Luydson Richardson Silva

Abstract excerpt

COVID-19, caused by the SARS-CoV-2 virus, has had a global impact, leading to high incidence and mortality rates worldwide. Host genetics significantly influence individual susceptibility to severe COVID-19. The C-type lectin domain family 4 member M (CLEC4M) gene plays an important role in SARS-...

Topics

Humans
Lectins, C-Type
COVID-19
Polymorphism, Single Nucleotide
Female
Male
Middle Aged
Brazil
Aged
Severity of Illness Index
SARS-CoV-2
Genetic Predisposition to Disease
Cross-Sectional Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Alleles

Adult

Gene Frequency

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 41062837
DOI: 10.1007/s00251-025-01386-8

Genes

CLEC4M

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41062837-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.